As an indispensable excipient in pharmaceuticals, the safety of empty capsules is directly related to the life and health of patients. However, what are the serious consequences if raw material suppliers are not strictly audited during the production process, or if raw materials are not subjected to incoming inspection? The most direct and fatal consequence is that the heavy metal chromium content in the capsule shells exceeds the safety limit (>2pm).
Marka hore, la'aanta hubinta alaab-qeybiyaha ayaa albaabka u furaysa qulqulka alaabta ceeriin ee hoose. Warshadaha wax-soo-saarka jelatin, oo ay kaxayso raadinta macaash aad u badan, qaar ka mid ah soosaarayaasha aan damiir lahayn ayaa laga yaabaa inay isticmaalaan qashinka maqaarka, oo loo yaqaan "maqaarka buluuga ah" si ay u karkariyo jelatin warshadaha. Qiimaha jelatin-warshadeedkan aad ayuu uga hooseeyaa kan jelatin-da dawooyinka, laakiin waxa uu ka soo jeedaa warshadaha haragga maqaarka. Maadaama haraggu ay ku lug leedahay isticmaalka ballaaran ee chromium{3}}oo ka kooban walxaha, waxa ku jira chromium-ka ku jira jelatin warshadeed aad buu u sarreeyaa. Iyadoo aan la hubin hantidhawr il adag iyo - xaqiijinta goobta alaab-qeybiyeyaasha, soo saarayaasha dawooyinka way ku adagtahay inay aqoonsadaan sharci-darrada isha alaabta ceeriin, si badheedh la'aan ah u isticmaalaan agabkan hoose.
Marka labaad, ka boodista tijaabada alaabta ceyriinka waxay u oggolaaneysaa alaabada ka sarreysa heerarka inay si toos ah u gaaraan bukaanka. Marka loo eego qawaaniinta Pharmacopoeia ee Shiinaha, waxa ku jira chromium ee kaabsal madhan waa in aanay ka badnaan 2ppm. Kani waa khad cas oo badbaado adag leh. Si kastaba ha noqotee, haddii shirkaddu ka boodo tallaabada kormeerka tayada ka dib iibsashada alaabta ceeriin, suurtagal maaha in la aqoonsado wasakhowga birta culus ee aan la arki karin indhaha qaawan. Marka jelatin-kan sare -chromium laga sameeyo qolof kaabsul ah oo laga buuxiyo daawo, waxay noqotaa "sonkor" lagu dahaadhay sun.
Waxyeellada chromium-ka xad-dhaafka ah ay u leedahay caafimaadka aadanaha lama dhayalsan karo. Chromium ayaa ku urura jidhka, iyo chromium hexavalent, gaar ahaan, aad bay sun u tahay. --cunista muddada dheer waxay dhaawici kartaa xubnaha sida beerka iyo kelyaha waxayna xitaa keeni kartaa khatarta kansarka. In kasta oo hal qaadasho laga yaabo in aanay keenin sumayn degdeg ah, isticmaalka muddada dheer ee dawooyinka kaabsulka ahi waxa ay shaki la'aan aasaysaa bam wakhti ah gudaha jidhka.
Marka la soo koobo, alaab-qeybiyeyaal aan la hubin ama aan la tijaabinalaabta ceeriinwaa sababaha asalka u ah chromium-ka xad-dhaafka ah ee kaabsalka. Tani ma aha oo kaliya fashilka ilaalinta tayada laakiin sidoo kale tixgelin la'aanta caafimaadka macaamiisha. Shirkadaha wax soo saarka dawooyinka waa inay u hoggaansamaan tayada aasaasiga ah, si adag u ilaaliyaan albaabbada xisaabinta iyo tijaabinta, oo ay xaqiijiyaan in kaabsal kastaaba yahay badbaado iyo saafi. Haddii ay jiraan wax su'aalo ah oo ku saabsan kaabsoosha madhan, Ku soo dhawoow la xiriir KornnacCaps.
